基因多态性对镇痛药物治疗神经病理性疼痛疗效的研究进展

刘蕾, 李雯婷, 王莱茵, 李玉珍, 冯智英, 饶跃峰

中国药学杂志 ›› 2022, Vol. 57 ›› Issue (9) : 677-683.

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中国药学杂志 ›› 2022, Vol. 57 ›› Issue (9) : 677-683. DOI: 10.11669/cpj.2022.09.001
综述

基因多态性对镇痛药物治疗神经病理性疼痛疗效的研究进展

  • 刘蕾1,2, 李雯婷2, 王莱茵1, 李玉珍2, 冯智英1, 饶跃峰1*
作者信息 +

Research Progress in Effects of Gene Polymorphism on Analgesic Drug Treatment for Neuropathic Pain

  • LIU Lei1,2, LI Wen-ting2, WANG Lai-yin1, LI Yu-zhen2, FENG Zhi-ying1, RAO Yue-feng1*
Author information +
文章历史 +

摘要

随着“精准用药”概念的提出,基因多态性对药物疗效的影响受到广泛关注,目前基因检测已成为评估药物疗效、预防药物不良反应的重要手段。临床用药实践证明在传统经验用药模式下镇痛药物的治疗效果个体差异明显,本文基于基因多态性对神经病理性疼痛镇痛药物的个体化用药予以综述,旨在为镇痛药物的合理安全用药提供参考,为医院药学部门开展药物基因检测提供理论依据。

Abstract

With the proposal of the conception precision medication, the influence of gene polymorphism on the efficacy of drugs has drawn widespread attention. Genetic testing has recently become an important strategy to evaluate drug efficacy and prevent adverse drug reactions. Clinical medication practice has proved that the therapeutic effects of analgesics under the traditional empirical medication model have significant individual differences. This article reviews the individualized therapeutic effects of neuropathic pain analgesics based on genetic polymorphisms, aiming to provide a clinical guidance for the safe and rational application of analgesics as well as a scientific evidence for the department of pharmacy to carry out drug genetic testing.

关键词

神经病理性疼痛 / 基因多态性 / 基因检测 / 精准用药 / 镇痛药 / 慢性疼痛

Key words

neuropathic pain / gene polymorphism / gene detection / precise medication / analgesic drug / chronic pain

引用本文

导出引用
刘蕾, 李雯婷, 王莱茵, 李玉珍, 冯智英, 饶跃峰. 基因多态性对镇痛药物治疗神经病理性疼痛疗效的研究进展[J]. 中国药学杂志, 2022, 57(9): 677-683 https://doi.org/10.11669/cpj.2022.09.001
LIU Lei, LI Wen-ting, WANG Lai-yin, LI Yu-zhen, FENG Zhi-ying, RAO Yue-feng. Research Progress in Effects of Gene Polymorphism on Analgesic Drug Treatment for Neuropathic Pain[J]. Chinese Pharmaceutical Journal, 2022, 57(9): 677-683 https://doi.org/10.11669/cpj.2022.09.001
中图分类号: R969   

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基金

浙江省中医药(中西医结合)重点学科建设计划-中西医结合临床药学项目资助(2017-XK-A37);浙江省药学会医院药学药事管理软科学研究基金项目资助(2019ZYYG02)
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